An idiotypic network model of AIDS immunopathogenesis.

Immunological Aspect of Meningococcal disease: An overview in Host- Bacteria Interaction

Meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. Meningococcal disease has a rapid onset with high mortality. The understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

Whitbrook, Amanda and Aickelin, Uwe and Garibaldi, Jon (2007) Idiotypic Immune Networks in Mobile Robot

Jerne’s idiotypic network theory postulates that the immune response involves inter-antibody stimulation and suppression as well as matching to antigens. The theory has proved the most popular Artificial Immune System (AIS) model for incorporation into behavior-based robotics but guidelines for implementing idiotypic selection are scarce. Furthermore, the direct effects of employing the techniq...

An epidemic model for the transmission dynamics of HIV/AIDS with different clinical stages

In this paper, a five–dimensional mathematical model is proposed for the transmission dynamics of HIV/AIDS within a population of varying size. In writing the model, we have divided the population under consideration into five sub classes of susceptible, infective, pre-AIDS, AIDS related complex and that of AIDS patients. The model has two non- negative equilibria namely, a disease free and the...

Evidence in favor of a role of idiotypic network in autoimmune hemolytic anemia induction: theoretical and experimental studies.

Formation dynamics of antibodies to rat erythrocytes (REs) and auto-antibodies to mouse erythrocytes were studied in an experimental model of autoimmune hemolytic anemia (AHA) in mice. The experimental conditions of AHA were simulated in a mathematical model of an immune network. It was found that maximal production of auto-antibodies and antibodies to REs do not synchronize. Antiserum, obtaine...

Estimating An ECM-AIDS Model For Urban-Area's Household Expenditure: The Case Of Iran